A konvallatoxin (CAS szám 508-75-8) egy glikozid, a gyöngyvirágból (Convallaria majalis) vonják ki. Hasonló a digitalishoz, szívproblémák esetén használják.
Fizikai tulajdonságok
Sűrűség: 1.41 g/cm3
Forráspont: 757.3 °C at 760 mmHg
Gőznyomás: 1.8E-26 mmHg
Gyulladáspont: 247.1 °C
Kémiai tulajdonságok
IUPAC név: (3S,5S,8R,9S,10S,13R,14S,17R)-5,14-dihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
Képlet: C29H42O10
Moltömeg: 550.64 g/mol
PubChem adatlap: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441852#x332
Toxicitási adatok
macska LD50 intraduodenalis 2100ug/kg (2.1mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
macska LD50 intraperitonealis 180ug/kg (0.18mg/kg) Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
macska LD50 intravénás 74ug/kg (0.074mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942.
macska LD50 szájon át 3650ug/kg (3.65mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
macska LDLo 50ug/kg (0.05mg/kg) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964.
béka LD50 szubcutan 440ug/kg (0.44mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
béka LDLo intravénás 300ug/kg (0.3mg/kg) Merck Index. Vol. 10, Pg. 357, 1983.
tengerimalac LD50 intraperitoneális 200ug/kg (0.2mg/kg) Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
tengerimalac LD50 intravénás 185ug/kg (0.185mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
tengerimalac LD50 szájon át > 50mg/kg (50mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
tengerimalac LD95 intraduodenalis 10490ug/kg (10.49mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
majom LDLo intravénás 90ug/kg (0.09mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
egér LD50 intraperitonealis 10mg/kg (10mg/kg) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.
egér LD50 intravénás 1mg/kg (1mg/kg) U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00462,
egér LD50 szájon át > 2gm/kg (2000mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
egér LD50 szubcutan 15mg/kg (15mg/kg) Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.
pig LDLo intraduodenalis 3170ug/kg (3.17mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
pig LDLo intravénás 50ug/kg (0.05mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
galamb LDLo intravénás 248ug/kg (0.248mg/kg) Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
patkány LD50 intravénás 15200ug/kg (15.2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 848, 1961.
http://en.wikipedia.org/wiki/Convallatoxin
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441852#x332
http://www.lookchem.com/CONVALLATOXIN/