Al(OH)3

Aluminium hydroxide

Source of the photo: 
https://www.scbt.com/p/aluminum-hydroxide-21645-51-2
Author of the description: 
VE
Al(OH)3

CHEMICAL SUBSTANCE DATASHEET

 

CHEMICAL SUBSTANCE IDENTIFICATION

Chemical name                 

Aluminium Hydroxide [1]

Synonyms                           

Alumina Hydrate, Aluminium hydrate, Hydrated alumina, etc [1]

IUPAC name

aluminium(3+) trihydroxide [1]

CAS No

21645-51-2

REACH registration number

fully registered

EC No

244-492-7

Molecular formula              

AlH3O3

Substance group/chemical family

mono-constituent substance

Appearance

Physical state

Odour

Form

Colour

 solid at 20°C and 1013 hPa [1]

odourless

powder

white

USES AND HANDLING ISSUES

Relevant identified uses

It is a compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc. [2]

Ingredient in household products  [2]

cables, textiles like carpets, epoxy casting resins, different applications in the chemical industry, SMC/ BMC as well as latex [3]

Handling considerations

 storage between +5°C and +30°C [4]

PHYSICO-CHEMICAL PROPERTIES

Molecular weight                                  

78.004  g/mol [1, 2]

Bulk density/Specific gravity

2.42 g/cm³ at 20°C [1, 2]

pH

8 - 9 (100 g/l, H₂O, 20 °C) (slurry) [3]

Particle size

 

EC

 

Melting point

300 °C  at   101 325 Pa [1, 2]

Boiling point

2 980 °C at 101 325 Pa [1]

Flash point

not applicable

Flammability

non flammable, based upon the use of this substance as a flame retardant in a number of industrial and consumer products and its chemical structure and known physical-chemical properties, the substance is known not to be flammable. [1]

flame retardance (dehydration at 200°C) [3]

Vapour density

 

Vapour pressure

<0.1 hPa (20 °C) [4]

Solubility in water

poorly soluble, with a water solubility of 0.00009 g/L at 20 °C. [1]

Solubility in organic solvents

Not applicable because  the substance is inorganic

Solubility in inorganic solvents

 

Hydrolysis

 

Ionicity in water

 

Surface tension

 

Dispersion properties

 

Explosiveness

it is not considered to be explosive [1]

Other properties

it is not considered to have any oxidising properties [1]

Hardness 3 (Mohs) [3]

thermal expansion: 15*10-6/K (at T 20-300 °C) [3]

Stability and reactivity

Chemical stability

 

Reactivity hazards

 

Corrosivity

 

Polimerization

 

Incompatibility with various substances

 

Special remarks on reactivity

 

Physical, chemical and biological coefficient

Koc

 

Kow

 

pKa

 

log Kp

 

Henry-constant

 

ENVIRONMENTAL FATE AND BEHAVIOUR

Artificial pollution sources

 

General terrestrial fate

 

General aquatic fate

 

General atmospheric fate

 

General persistence and degradability

 

Abiotic degradation and metabolites

 

Biodegradation and metabolites

For an inorganic substance for which the chemical assessment is based on the elemental concentration, biotic degradation is an irrelevant process. [1]

Bioconcentration

The available evidence shows the absence of aluminium biomagnification across trophic levels both in aquatic and terrestrial food chains. The existing information suggests not only that aluminium does not biomagnify, but rather that it tends to exhibit biodilution at higher trophic levels in the food chain. [1]

Volatilization

 

Photolysis

 

Hydrolysis

 

Soil adsorption and mobility

 

ENVIRONMENTAL CONCENTRATIONS

Measured data

 

 

ECOTOXICOLOGICAL INFORMATION

General adverse effects on ecosystem

Acute toxicity (LC50, EC50)

Aquatic systems

 

Terrestrial systems

 

Chronic toxicity (NOEC, LOEC)

Aquatic systems

 

Terrestrial systems

 

HUMAN HEALTH EFFECTS and PROTECTION

Routes of human exposures

 

General effects

 

Endocrine disruption

 

Mutagenicity

 No adverse effect observed [1]

Carcinogenicity

Based on the weight of evidence approach for carcinogenicity no classification is required for aluminium hydroxide according to DSD (67/548/EEC) or CLP (1272/2008/EC) classification criteria. [1]

Reprotoxicity

Based on the read-across from aluminium compounds for the toxicity to reproduction or development of aluminium hydroxide, no classification is required according to DSD (67/548/EEC) or CLP (1272/2008/EC) classification criteria. [1]

Teratogenicity

No adverse effect observed [1]

Skin, eye and respiratory irritations

Aluminium hydroxide is unlikely to lead to skin, eye or respiratory irritative effects. [1] The available human evidence is limited in amount but supports a low sensitisation potential for aluminium hydroxide. [1]

Metabolism:

absorption, distribution & excretion

 

Exposure limits

 TLV (inhalable fraction): 4 mg/m3; TLV (respirable fraction): 1.5 mg/m3; pregnancy risk group: D [2]

Drinking water MAC

 

Other information

There are no studies available on the repeated dose toxicity of aluminium hydroxide by the oral, inhalation and dermal route. [1]

Overall, based on the read-across from aluminium compounds for the neurotoxicity of aluminium hydroxide, no classification is required according to DSD (67/548/EEC) or CLP (1272/2008/EC) classification criteria. [1]

 

Animal toxicity data

Acute toxicity (LD50)

It is recommended that aluminium hydroxide is not to be classified for acute oral, dermal and inhalation toxicity. [1]

Oral LD50 (rat) > 2000 mg/kg bw  [1]

Inhalation LC50 (rat) >  2.3 mg/L  [1]

Chronic toxicity (NOEL, LOEL)

 

ENVIRONMENTAL STANDARDS AND REGULATIONS

EINECS regulation

̵

OSHA regulations etc.

 

 

 

OTHER INFORMATION, SPECIAL REMARKS

Classification and proposed labelling with regard to toxicological data

No signal word [1]

As a result of the hazard assessment and PBT/vPvB assessment it is found that substance aluminium hydroxide (CAS# 21645-51-2) does not meet the criteria for classification as hazardous (according to Directives 67/548/EEC and 1272/2008/EC) nor is it considered to be a PBT/vPvB. An exposure assessment and the subsequent step of risk characterisation is not required. [1]

 

 

CREATED, LAST UPDATE

Created

2019. 09. 04

Last update

2019. 09. 11

REFERENCES

[1] ECHA, Aluminium hydroxide https://echa.europa.eu/hu/registration-dossier/-/registered-dossier/15529,  Accessed 2019.09.04

[2] PUBCHEM,  Aluminum Hydroxide (Compound), https://pubchem.ncbi.nlm.nih.gov/compound/Aluminum-hydroxide#section=Computed-Properties,  Accessed 2019.09.05

[3] The mineral engineers, Aluminium hydroxide http://www.hpfminerals.kr/en/product-overview/aluminium-hydroxide,  Accessed 2019.09.11

[4] Safety Data Sheet for Aluminium-hydroxide 101091

http://www.merckmillipore.com/HU/hu/product/msds/MDA_CHEM-101091?Origin=PDP,   Accessed 2019.09.11